Our Publications
Research Articles
Shiu, F.H., Wong, J.C., Bhattacharya, D., Kuranaga, Y., Parag, R.R., Alsharif, H.A., Bhatnagar, S., Van Meir, E.G., Escayg, A. Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression. Basic Clin Pharmacol Toxicol 2023. PMID: 37337931.
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Shapiro L., Escayg, A., Wong, J.C. Cannabidiol increases seizure resistance and improves behavior in an Scn8a mouse model. Frontiers in Pharmacology 2022: 13: 815950. PMID: PMC8826257.
Shiu, F, Wong, J.C., Purcell, R.H., Lala, T., Owino, S., Zhu, D., Van Meir, E.G., Hall, R.A., Escayg, A. Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development. Experimental Neurology 2022: 351: 113994. PMID: 35114205.
Wong, J.C., Butler, K.M., Shapiro, L., Thelin, J.T., Mattison, K.A., Garber, K.B., Goldenberg, P.C., Kubendran, S., Schaefer, G.B., Escayg, A. Pathogenic in-frame variants in SCN8A: expanding the genetic landscape of SCN8A-associated disease. Frontiers in Pharmacology 2021: 12: 748415. PMID: PMC8635767.
Wong, J.C., Grieco, S.F., Dutt, K., Chen, L., Thelin, J.T., Inglis, G.A.S., Parvin, S., Garraway, S.M., Xu, X., Goldin, A.L., Escayg, A. Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacology 2021: PMID: 33658654.
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Wong, J.C., Shapiro, L., Thelin, J.T., Heaton, E.C., Zaman, R.U., D’Souza, M.J., Murnane, K.S., Escayg, A. Neurobiology of Disease, 2021: 147: 105147. PMID: PMC7726060.
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Inglis, G.A.S., Wong, J.C., Butler, K.M., Thelin J.T., Mistretta, O.C., Wu, X., Lin, X., English, A.W., Escayg, A. Mutations in the Scn8a DIIS4 voltage sensor reveal new distinctions among hypomorphic and null Nav1.6 sodium channels. Genes, brain and behavior 2020: 19(4): e12612. PMID: 31605437.
Shapiro, L., Wong, J.C., Escayg, A. Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice. Epilepsia 2019: 60(12): 2359-2369. PMID: PMC6911915.
Wong, J.C., Thelin, J.T., Escayg, A. Donepezil increases resistant to induced seizures in a mouse model of Dravet syndrome. Annals of Clinical Translational Neurology 2019: 6(8): 1566-1571. PMID: PMC6689688.
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Wong, J.C., Makinson, C.D., Lamar, T., Cheng, Q., Wingard, J.C., Terwilliger, E.F., Escayg, A. Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy. Scientific Reports 2018: 8: 126. PMID: PMC5760706.
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Giddens, M.M., Wong, J.C., Schroeder, J.P., Farrow, E.G., Smith, B.M., Owino, S., Soden, S.E., Meyer, R.C., Saunders, C., LePichon, J.B., Weinshenker, D., Escayg, A., Hall, R.A. GPR37L1 Modulates Seizure Susceptibility: Evidence from Mouse Studies and Analyses of a Human GPR37L1 Variant. Neurobiology of Disease 2017: 106: 181-190. PMID: PMC5569905.
Rha, J., Jones, S.K., Fidler, J., Morris, K.J., Banerjee, A., Wong, J.C., Inglis, G.A.S., Shapiro, L., Deng, Q., Hanif, A.M., Pardue, M.T., Schaffer, T.A., Seyfried, N.T., Moberg, K.H., Bassell, G.J., Escayg, A., García, P.S., Corbett, A.H. The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Human Molecular Genetics, 2017: 26(19): 3663-3681. PMID: PMC5886104.
Makinson, C.D., Tanaka, B.S., Sorokin, J. Wong, J.C., Christian, C.A., Goldin, A.L., Escayg, A.*, Huguenard, J.R.* Regulation of thalamic and cortical network synchrony by Scn8a. Neuron 2017: 93: 1165-1179. PMCID: PMC5393918. *Co-senior authors.
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Lamar, T., Vanoye, C.G., Calhoun, J., Wong, J.C., Dutton, S.B., Jorge, B.S., Velinov, M., Escayg, A*., Kearney, J.A*. SCN3A deficiency associated with increased seizure susceptibility. Neurobiology of Disease 2017: 102: 38-48. PMID: 28235671. *Corresponding authors.
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Wong, J.C., Dutton, S,B.B., Collins, S.D., Schachter, S., Escayg, A. Huperzine A provides robust and sustained protection against induced seizures in Scn1a mutant mice. Frontiers in Pharmacology 2016: 7: 357. PMCID: PMC5065986. (Press release on this study, November 9, 2016, http://news.emory.edu/stories/2016/11/hupA_escayg_dravet/index.html).
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Commentaries
​Wong, J.C. Cannabidiol keeps hippocampal hyperactivity in check. Epilepsy Currents, 2023. Accepted, Online July 19, 2023.
Wong, J.C. Gaining awareness of increasingly persistent SCN1A mutations. Epilepsy Currents, 2023, 23(3): 179-181.
Wong, J.C. Overcoming barriers to improve treatments in epilepsy. Epilepsy Currents, 2022, 22(5): 321-323.
Wong, J.C. On the right Trk: Towards an effective treatment for Dravet syndrome. Epilepsy Currents, 2022, 22(6): 387-389.
Jenkins, A., Escayg, A. Reply: Novel GABRA2 variants in epileptic encephalopathy and intellectual disability with seizures. Brain 2019: 142(5): e16.
Wong, J.C., Escayg, A. From DREADD to treatment in temporal lobe epilepsy. Epilepsy Currents 2019: 19(1): 47-48.
Wong, J.C., Escayg, A. Turning up the heat on endocannabinoid signaling. Epilepsy Currents 2016: 16(6): 414-415.
Wong, J.C., Escayg, A. Fgf13 identified as a novel cause of GEFS+. Epilepsy Currents 2016: 16(2): 112-113.
Wong, J.C., Escayg, A. Illuminating the cerebellum as a potential target for treating epilepsy. Epilepsy Currents 2015: 15(5): 277-278.
Goldin, A.L., Escayg, A. Complex genetic interactions in a mouse model of absence epilepsy. Epilepsy Currents 2015: 15(1): 50-51.
Escayg, A., Wong, J. Towards routine genetics-based diagnoses for the epileptic encephalopathies. Epilepsy Currents 2014: 14: 158-160.